Publications

T. N. Phan, C. H. Fan, H. C. Wang, H. L. Liu, Y. C. Lin*, and C. K. Yeh* (2024, Nov). Modulation of GABAergic Neurons in Acute Epilepsy Using Sonogenetics. Journal of Controlled Release. (Accepted).

C. H. Fan, W. C. Lo, C. H. Huang, T. N. Phan, and C. K. Yeh* (2024, Sep). Super-Resolution Ultrasound Imaging for Analysis of Microbubbles Cluster by Acoustic Vortex Tweezers. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. (Accepted)

C. W. Hu, Z. H. Hsieh, C. H. Huang, M. L. Li, and C. K. Yeh*, "Acoustic Vortex-based Dynamic Lens for Light Focusing and Steering," Opt. Lett., 49, 6341-6344, 2024. (Editors' Pick) (IF=3.1, Optics, 37/119)

Z. H. Hsieh, C. Y. Lai, N. H. Chen, and C. K. Yeh*, "Acoustic Vortex-Assisted Thrombolysis Treatment in a Pulmonary Embolism Model Using a Miniature Ultrasound Catheter," J. Med. Biol. Eng., 44, 478-487, 2024. (JMBE Annual Excellent Paper Award) 

C. W. Lin, M. H. Cheng, C. H. Fan, H. H. Chen*, and C. K. Yeh*, "Focused Ultrasound Stimulation of Infralimbic Cortex Attenuates Reinstatement of Methamphetamine-Induced Conditioned Place Preference in Rats," Neurotherapeutics, 21(3), e00328, 2024.

C. H. Fan, C. Y. Tsai, C. Y. Lai, Y. F. Liou, J. K. Lee, and C. K. Yeh*, "Feasibility of in Vitro Calcification Plaque Disruption Using Ultrasound-Induced Microbubble Inertial Cavitation," Ultrasonics, 138, 107238, 2024.

C. W. Lin, C. H. Fan, C. K. Yeh*, "The relationship between surface drug distribution of Dox-loaded microbubbles and drug release/cavitation behaviors with ultrasound," Ultrason. Sonochem., 120, 106728, 2024.

H. H. Kuo, Y. H. Lai, P. L. Lin, H. H. Chen, C. L. Hung, Y. M Liu*, C. K. Yeh, "Effects of Canagliflozin on Cardiac Remodeling and Hemodynamic Parameters in Patients with Type 2 Diabetes Mellitus, " Sci. Rep., 13, 21327, 2023. 

H. C. Wang, P. T. Nhan, C. L. Kao, C. K. Yeh*, Y. C. Lin*, "Genetically Encoded Mediators for Sonogenetics and Their Applications in Neuromodulation," Front. Cell. Neurosci., 17, 1326279, 2023.

Z. H. Hsieh, Y. C. Lin, C. H. Fan*, C. K. Yeh*, "Electrowetting-Driven Liquid Lens for Ultrasound: Enabling Controllable Focal Length and Flexible Beam Steering," Ultrasonics, 135, 107147, 2023.

T. N. Phan, C. H. Fan, C. K. Yeh*, "Application of Ultrasound to Enhancing Stem Cells Associated Therapies," Stem Cell Rev. Rep., 19, 1709-1725, 2023.

Y. J. Ho, H. L. Cheng, L. D. Liao, Y. C. Lin, Y. C. Lin, H. C. Tsai*, C. K. Yeh*, "Oxygen-loaded microbubble-mediated sonoperfusion and oxygenation for neuroprotection after ischemic stroke reperfusion," Biomater. Res., 27(65), 2023.

C. H. Fan, H. C. Tsai, Y. S. Tsai, H. C. Wang, Y. C. Lin, P. H. Chiang, N. Wu, M. H. Chou, Y. J. Ho, Z. H. Lin, C. K. Yeh*, "Selective Activation of Cells by Piezoelectric Molybdenum Disulfide Nanosheets with Focused Ultrasound," ACS Nano, 17(10), 9140-9154, 2023.

Y. J. Ho*, H. C. Hsu, B. H. Wu, Y. C. Lin, L. D. Liao, C. K. Yeh*, "Preventing ischemia-reperfusion injury by acousto-mechanical local oxygen delivery," J. Control. Release, 356, 481-492, 2023.

C. H. Fan, N. Wu, C. K. Yeh*, "Enhanced Sonodynamic Therapy by Carbon Dots-Shelled Microbubbles with Focused Ultrasound," Ultrason. Sonochem., 94, 106342, 2023.

P. H. Chiang, C. H. Fan, Q. Jin, C. K. Yeh*, "Enhancing Doxorubicin delivery in Solid Tumor by Superhydrophobic Amorphous Calcium Carbonate-Doxorubicin Silica Nanoparticles with Focused Ultrasound," Mol. Pharm., 19(11), 3894-3905, 2022.

C. H. Fan, Y. J. Ho, C. W. Lin, N. Wu, P. H. Chiang, C. K. Yeh*, "State-of-the-Art of Ultrasound-Triggered Drug Delivery from Ultrasound-Responsive Drug Carriers," Expert Opin. Drug Deliv., 19(8), 997-1009, 2022.

N. Wu, C. H. Fan, C. K. Yeh*, "Ultrasound-Activated Nanomaterials for Sonodynamic Cancer Theranostics," Drug Discov. Today, 27(6), 1590-1603, 2022.

Y. J. Ho, D. T. Thao, C. K. Yeh*, "Overcoming Hypoxia-Induced Drug Resistance via Promotion of Drug Uptake and Reoxygenation by Acousto–Mechanical Oxygen Delivery," Pharmaceutics, 14(5), 902, 2022. (This article belongs to the Special Issue Ultrasonic Technologies in Imaging and Drug Delivery)

Z. H. Hsieh, C. H. Fan, M. L. Li*, C. K. Yeh*, "Ultrasound-Guided System for Light Focusing Using Microbubbles Generated from Polytetrafluoroethylene Nanoparticles," Appl. Phys. Lett., 120(5), 053701, 2022.

C. W. Lin, C. H. Fan, C. K. Yeh*, " The Impact of Surface Drug Distribution on the Acoustic Behavior of DOX-loaded Microbubbles," Pharmaceutics, 13(12), 2080, 2021.

W. C. Lo, Y. L. Huang, C. H. Fan, C. K. Yeh*, "3-D Ultrafast Ultrasound Imaging of Microbubbles Trapped Using an Acoustic Vortex," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 68(12), 3507-3514, 2021.

I. N. Lo, P. C. Hsu, Y. C. Huang, C. K. Yeh, Y. C. Yang, J. C. Wang*, "Dynamic Ultrasound Assessment of Median Nerve Mobility Changes following Corticosteroid Injection and Carpal Tunnel Release in Patients with Carpal Tunnel Syndrome," Front. Neurol., 12, 710511, 2021.

 Y. J. Ho, C. C. Huang, C. H. Fan, H. L. Liu*, C. K. Yeh*, "Ultrasonic Technologies in Imaging and Drug Delivery," Cell. Mol. Life Sci., 78(17-18), 6119-6141, 2021.

C. H. Fan, K. C. Wei, N. H. Chiu, E. C. Liao, H. C. Wang, R. Y. Wu, Y. J. Ho, H. L. Chan, T. S. A. Wang, Y. Z. Huang, T. H. Hsieh, C. H. Lin, Y. C. Lin*, C. K. Yeh*, "Sonogenetic-based Neuromodulation for the Amelioration of Parkinson's Disease," Nano Lett., 21(14), 5967-5976, 2021.

W. Y. Yang, L. C. Chen, Y. T. Jhuang, Y. J. Lin, P. Y. Hung, Y. C. Ko, M. Y. Tsai, Y. W. Lee, L. W. Hsu, C. K. Yeh, H. H. Hsu*, C. C. Huang*, "Injection of Hybrid 3D Spheroids Composed of Podocytes, Mesenchymal Stem Cells, and Vascular Endothelial Cells into the Renal Cortex Improves Kidney Function and Replenishes Glomerular Podocytes," Bioeng. Transl. Med., 6(2), e10212, 2021.

Y. J. Ho, H. C. Chang, C. W. Lin, C. H. Fan*, Y. C. Lin, K. C. Wei, C. K. Yeh*, "Oscillatory Behavior of Microbubbles Impacts Efficacy of Cellular Drug Delivery," J. Control. Release, 333, 316-327, 2021.

C. H. Fan, W. F. Kao, S. T. Kang, Y. J. Ho, C. K. Yeh*, "Exploring the Acoustic and Dynamic Characteristics of Phase-Change Droplets," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 68(4), 1051-1061, 2021.

P. C. Li, S. C. Chen, Y. J. Hsueh, Y. C. Shen, M. Y. Tsai, L. W. Hsu, C. K. Yeh, H. C. Chen, C. C Huang*, "Gelatin Scaffold with Multifunctional Curcumin-loaded Lipid-PLGA Hybrid Microparticles for Regenerating Corneal Endothelium," Mater. Sci. Eng. C-Mater. Biol. Appl., 120, 111753, 2021.

 W. C. Lo, C. H. Fan, Y. J. Ho, C. W. Lin, C. K. Yeh*, "Tornado-Inspired Acoustic Vortex Tweezer for Trapping and Manipulating Microbubbles," Proc. Natl. Acad. Sci. U. S. A., 118(4), 11794-11819, 2021. (Selected as feature article "In This Issue")

A. C. del Valle, C. K. Yeh, Y. F. Huang*, "Near Infrared‐Activatable Platinum‐Decorated Gold Nanostars for Synergistic Photothermal/Ferroptotic Therapy in Combating Cancer Drug Resistance," Adv. Healthc. Mater., 9(20): e2000864, 2020.

Z. H. Hsieh, C. H. Fan, Y. J. Ho, M. L. Li, C. K. Yeh*, "Improvement of Light Penetration in Biological Tissue Using an Ultrasound-induced Heating Tunnel," Sci Rep, 10(1), 17406, 2020.

Y. Shen, L. Hua, C. K. Yeh, L. Shen, M. Ying, Z. Zhang, G. Liu, S. Li, S. Chen, X. Chen*, X. Yang*, "Ultrasound with Microbubbles Improves Memory, Ameliorates Pathology and Modulates Hippocampal Proteomic Changes in a Triple Transgenic Mouse Model of Alzheimer’s Disease," Theranostics, 10(25), 11794-11819, 2020.

Y. J. Ho, J. P. Li, C. H. Fan, H. L. Liu*, C. K. Yeh*, "Ultrasound in Tumor Immunotherapy: Current Status and Future Developments," J. Control. Release, 323, 12-23, 2020. (invited review article)

H. C. Lin, C. H. Fan, C. K. Yeh*, "Dual-Frequency Chirp Excitation for Passive Cavitation Imaging in the Brain," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 67(6), 1127-1140, 2020.

C. Y. Wu, R. Y. Huang, E. C. Liao, Y. C. Lin, C. W. Chang, H. L. Chan, Y. Z. Huang, T. H. Hsieh, C. H. Fan*, C. K. Yeh*, " A preliminary study of Parkinson's gene therapy via sono-magnetic sensing gene vector for conquering extra/intracellular barriers in mice," Brain Stimul., 13(3), 785-799, 2020.

C. Y. Cho, T. H. Chiang, L. H. Hsieh, W. Y. Yang, H. H. Hsu, C. K. Yeh, C. C. Huang*, J. H. Huang*, "Development of a Novel Hanging Drop Platform for Engineering Controllable 3D Microenvironments," Front. Cell Dev. Biol., 8, 327, 2020.

Y. J. Ho, H. C. Hsu, S. T. Kang, C. H. Fan, C. W. Chang, C. K. Yeh*, "Ultrasonic Transdermal Delivery System with Acid-Base Neutralization-Generated CO2 Microbubble Cavitation," ACS Appl. Bio Mater., 3(4), 1968-1975, 2020.

Y. J. Ho, C. H. Wu, Q. Jin, C. Y. Lin, P. H. Chiang, N. Wu, C. M. Yang, C. K. Yeh*, "Superhydrophobic Drug-loaded Mesoporous Silica Nanoparticles Capped with β-cyclodextrin for Ultrasound Image-guided Combined Antivascular and Chemo-Sonodynamic Therapy," Biomaterials, 232, 119723, 2020.

Y. S. Huang, C. H. Fan, N. Hsu, N. H. Chiu, C. Y. Wu, C. Y. Chang, B. H. Wu, S. R. Hong, Y. C. Chang, Anthony Y. T. Wu, Vanessa Guo, Y. C. Chiang, W. C. Hsu, L. Y. Chen, Charles P. K. Lai, C. K. Yeh*, Y. C. Lin*, "Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-sensing Protein," Nano Lett., 20(2), 1089-1100, 2020.

C. Y. Wu, C. H. Fan, N. H. Chiu, Y. C. Lin, C. K. Yeh*, "Targeted Delivery of Engineered Auditory Sensing Protein for Ultrasound Neuromodulation in the Brain," Theranostics, 10(8), 3546-3561, 2020. 

C. H. Wu, H. L. Liu, C. T. Ho, P. H. Hsu, C. H. Fan, C. K. Yeh, S. T. Kang, W. S. Chen, F. N.  Wang, H. H. Peng*, "Real-Time Monitoring of Acoustic Cavitation in Microbubble-Presented Focused Ultrasound Exposure Using Gradient-Echo MRI," J. Magn. Reson. Imaging, 51(1), 311-318, 2020.

Y. L. Lee, S. Y. Chu, Y. L. Huang, W. H. Chan, M. H. Cheng, Y. H. Lin, T. Y. Chang, C. K. Yeh, P. H. Tsui*, "Characterization of Limb Lymphedema Using the Statistical Analysis of Ultrasound Backscattering," Quant. Imaging Med. Surg., 10(1), 48-56, 2020.

C. Y. Lin, C. H. Tsai, L. Y. Feng, W. Y. Chai, C. J. Lin, C. Y. Huang, K. C. Wei, C. K. Yeh, C. M. Chen*, H. L. Liu*, "Focused Ultrasound-Induced Blood Brain-Barrier Opening Enhanced Vascular Permeability for GDNF Delivery in Huntington’s Disease Mouse Model," Brain Stimul., 12(5), 1143-1150, 2019.

Y. J. Ho, S. W. Chu, E. C. Liao, C. H. Fan, H. L. Chan, K. C. Wei, C. K. Yeh*, "Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound," Theranostics, 9(24), 7370-7383, 2019. (inside front cover)

H. J. Chiou, C. K. Yeh, H. E. Hwang, Y. Y. Liao*, "Efficacy of Quantitative Muscle Ultrasound Using Texture-Feature Parametric Imaging in Detecting Pompe Disease in Children," Entropy, 21(7), 714, 2019.

T. T. Kuo, C. H. Wang, J. Y. Wang, H. J. Chiou, C. H. Fan, C. K. Yeh*, "Concurrent Osteosarcoma Theranostic Strategy using Contrast-Enhanced Ultrasound and Drug-Loaded Bubbles," Pharmaceutics, 11(5), 223, 2019.

Y. Y. Liao, C. K. Yeh, K. C. Huang, P. H. Tsui, K. C. Yang*, "Metabolic Characteristics of a Novel Ultrasound Quantitative Diagnostic Index for Nonalcoholic Fatty Liver Disease," Sci Rep, 9(1), 7922, 2019.

K. C. Yang, Y. Y. Liao, P. H. Tsui, C. K. Yeh*, "Ultrasound Imaging in Nonalcoholic Liver Disease: Current Applications and Future Developments," Quant. Imaging Med. Surg., 9(4), 546-551, 2019. 

C. H. Fan, T. W. Wang, Y. K. Hsieh, C. F. Wang, Z. Gao, A. Kim, Y. Nagasaki, C. K. Yeh*, "Enhancing Boron Uptake in Brain Glioma by a Boron-Polymer/Microbubble Complex with Focused Ultrasound," ACS Appl. Mater. Interfaces, 11(12), 11144-11156, 2019.

Y. J. Ho, C. C. Wu, Z. H. Hsieh, C. H. Fan, C. K. Yeh*, "Thermal-Sensitive Acoustic Droplets for Dual-Mode Ultrasound Imaging and Drug Delivery," J. Control. Release, 291, 26-36, 2018.

Y. H. Lin, Y. Y. Liao, C. K. Yeh, K. C. Yang, P. H. Tsui*, "Ultrasound Entropy Imaging of Nonalcoholic Fatty Liver Disease: Association with Metabolic Syndrome," Entropy, 20(12), 893, 2018.

H. Liu, M. Zhou, Z. Sheng, Y. Chen, C. K. Yeh, W. Chen, J. Liu, X. Liu, F. Yan*, H. Zheng, "Theranostic Nanosensitizers for Highly Efficient MR/Fluorescence Imaging‐guided Sonodynamic Therapy of Gliomas," J. Cell. Mol. Med., 22(11), 5394–5405, 2018.

C. H. Fan, Y. T. Lin, Y. J. Ho, C. K. Yeh*, "Spatial–temporal Cellular Bioeffects from Acoustic Droplet Vaporization," Theranostics, 8(20), 5731-5743, 2018.

C. Zhang, M. Shen, F. Teng, P. Li, F. Gao, J. Tu, L. Luo, C. K. Yeh, D. Zhang*, "Ultrasound-Enhanced Protective Effect of Tetramethylpyrazine via the ROS/HIF-1A Signaling Pathway in an in Vitro Cerebral Ischemia/Reperfusion Injury Model," Ultrasound Med. Biol., 44(8), 1786-1798, 2018.

C. H. Fan, Y. H. Lee, Y. J. Ho, C. H. Wang, S. T. Kang, C. K. Yeh*, "Macrophages as Drug Delivery Carriers for Acoustic Phase-Change Droplets," Ultrasound Med. Biol., 44(7), 1468-1481, 2018.

Z. Zhou, D. I. Tai, Y. L. Wan, J. H. Tseng, Y. R. Lin, S. Wu, K. C. Yang, Y. Y. Liao, C. K. Yeh, P. H. Tsui*, "Hepatic Steatosis Assessment with Ultrasound Small-Window Entropy Imaging," Ultrasound Med. Biol., 44(7), 1327-1340, 2018.

Y. J. Ho, T. C. Wang, C. H. Fan, C. K. Yeh*, "Spatially Uniform Tumor Treatment and Drug Penetration by Regulating Ultrasound with Microbubbles," ACS Appl. Mater. Interfaces, 10(21), 17784-17791, 2018. 

Y. J. Ho, Y. J. Chiang, S. T. Kang, C. H. Fan, C. K. Yeh*, "Camptothecin-Loaded Fusogenic Nanodroplets as Ultrasound Theranostic Agent in Stem Cell-mediated Drug-Delivery System," J. Control. Release, 278, 100-109, 2018. 

H. J. Chen, X. B. Zhou, A. L. Wang, B. Y. Zheng, C. K. Yeh, J. D. Huang*, "Synthesis and Biological Characterization of Novel Rose Bengal Derivatives with Improved Amphiphilicity for Sono-Photodynamic Therapy," Eur. J. Med. Chem., 145, 86-95, 2018.

M. T. Tsai, J. W. Zhang, K. C. Wei, C. K. Yeh, H. L. Liu*, "Assessment of Temporary Cerebral Effects Induced by Focused Ultrasound with Optical Coherence Tomography Angiography," Biomed. Opt. Express, 9(2), 507-517, 2018. 

Q. Jin, C. Y. Lin, Y. C. Chang, C. M. Yang*, C. K. Yeh*, "Roles of Textural and Surface Properties of Nanoparticles in Ultrasound-responsive Systems," Langmuir, 34(4), 1256-1265, 2018.

C. H. Fan, W. E. Huang, Y. S. Huang, A. A. Lee, S. Y. Ho, C. L. Wang, Y. L. Kao, Y. L. Lian, T. Ueno, T. S. Wang, C. K. Yeh, Y. C. Lin*, "Manipulating Cellular Activities Using an Ultrasound-Chemical Hybrid Tool," ACS Synth. Biol., 6(11), 2021-2027, 2017.

Y. J. Ho, Z. C. Wang, C. H. Fan, C. K. Yeh*, "Current Progress in Antivascular Tumor Therapy," Drug Discov. Today, 22(10), 1503-1515, 2017.

M. H. Luo, C. K. Yeh, B. Situ, J. S. Yu, B. C. Li, Z. Y. Chen*, "Microbubbles: A Novel Strategy for Chemotherapy," Curr. Pharm. Design, 23(23), 3383-3390, 2017. 

C. H. Fan, C. Y. Lin, H. L. Liu*, C. K. Yeh*, "Ultrasound Targeted CNS Gene Delivery for Parkinson’s Disease Treatment," J. Control. Release, 261, 246-262, 2017.

Y. Shen*, Z. Pi, F. Yan, C. K. Yeh, X. Zeng, X. Diao, Y. Hu, S. Chen, X. Chen, H. Zheng," Enhanced Delivery of Paclitaxel Liposomes Using Focused Ultrasound with Microbubbles for Treating Nude Mice Bearing Intracranial Glioblastoma Xenografts," Int. J. Nanomed., 12, 5613-5629, 2017.

E. L. Chang, C. Y. Ting, P. H. Hsu, Y. C. Lin, E. C. Liao, C. Y. Huang, Y. C. Chang, H. L. Chan, C. S. Chiang, H. L. Liu, K. C. Wei, C. H. Fan*, C. K. Yeh*, "Angiogenesis-targeting Microbubbles Combined with Ultrasound-Mediated Gene Therapy in Brain Tumors," J. Control. Release, 255, 164-175, 2017.

P. Y. Chen, C. K. Yeh, P. H. Hsu, C. Y. Lin, C. Y. Huang, K. C. Wei*, H. L. Liu*, "Drug-carrying Microbubbles as a Theranostic Tool in Convection-Enhanced Delivery for Brain Tumor Therapy," Oncotarget, 8(26), 42359-42371, 2017.

Q. Jin, C. Y. Lin, S. T. Kang, Y. C. Chang, H. Zheng, C. M. Yang*, C. K. Yeh*, "Superhydrophobic Silica Nanoparticles as Ultrasound Contrast Agents," Ultrason. Sonochem., 36, 262-269, 2017. 

S. K. Wu, P. C. Chu, W. Y. Chai, S. T. Kang, C. H. Tsai, C. H. Fan, C. K. Yeh*, H. L. Liu*, "Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening," Sci Rep, 7, 46689, 2017. 

Y. J. Ho, C. K. Yeh*, "Theranostic Performance of Acoustic Nanodroplet Vaporization-Generated Bubbles in Tumor Intertissue," Theranostics, 7(6), 1477-1488, 2017.

K. W. Huang, J. J. Chieh*, C. K. Yeh, S. H. Liao, Y. Y. Lee, P. Y. Hsiao, W. C. Wei, H. C. Yang, H. E. Horng, "Ultrasound-Induced Magnetic Imaging of Tumors Targeted by Biofunctional Magnetic Nanoparticles," ACS Nano, 11(3), 3030-3037, 2017.

D. H. Wan, B. Y. Zheng, M. R. Ke, J. Y. Duan, Y. Q. Zheng, C. K. Yeh, J. D. Huang, "C-Phycocyanin as a Tumour-Associated Macrophage-Targeted Photosensitiser and a Vehicle of Phthalocyanine for Enhanced Photodynamic Therapy," Chem. Commun., 53(29), 4112-4115, 2017.

Y. J. Ho, C. K. Yeh*, "Concurrent Anti-Vascular Therapy and Chemotherapy in Solid Tumors Using Drug-Loaded Acoustic Nanodroplet Vaporization," Acta Biomater., 49, 472-485, 2017.

M. R. Ke, S. F. Chen, X. H. Peng, Q. F. Zheng, B. Y. Zheng, C. K. Yeh, J. D. Huang*, "A Tumor-Targeted Activatable Phthalocyanine-Tetrapeptide-Doxorubicin Conjugate for Synergistic Chemo-Photodynamic Therapy," Eur. J. Med. Chem., 127, 200-209, 2017.

H. H. Peng*, C. H. Wu, S. T. Kang, J. W. Zhang, H. L. Liu, W. S. Chen, C. H. Wang, C. K. Yeh, "Real-Time Monitoring of Inertial Cavitation Effects of Microbubbles by Using MRI: In Vitro Experiments," Magn. Reson. Med., 77(1), 102-111, 2017.

M. T. Tsai, J. W. Zhang, Y. H. Liu, C. K. Yeh, K. C. Wei, H. L. Liu*, " Acoustic-actuated optical coherence angiography," Opt. Lett., 41(24), 5813-5816, 2016. 

C. H. Fan, E. L. Chang, C. Y. Ting, Y. C. Lin, E. C. Liao, C. Y. Huang, Y. C. Chang, H. L. Chan, K. C. Wei, C. K. Yeh*, "Folate-Conjugated Gene-Carrying Microbubbles with Focused Ultrasound for Concurrent Blood-Brain Barrier Opening and Local Gene Delivery," Biomaterials, 106, 46-57, 2016.

Y. Y. Liao, K. C. Yang, M. J. Lee, K. C. Huang, J. D. Chen, C. K. Yeh*, "Multifeature Analysis of an Ultrasound Quantitative Diagnostic Index for Classifying Nonalcoholic Fatty Liver Disease," Sci Rep, 6(1), 35083, 2016.

P. C. Chu, W. Y. Chai, C. H. Tsai, S. T. Kang, C. K. Yeh, H. L. Liu*, "Focused Ultrasound-Induced Blood-Brain Barrier Opening: Association with Mechanical Index and Cavitation Index Analyzed by Dynamic Contrast-Enhanced Magnetic-Resonance Imaging," Sci Rep, 6, 33264, 2016. 

Q. Jin, S. T. Kang, Y. C. Chang, H. Zheng*, C. K. Yeh*, "Inertial Cavitation Initiated by Polytetrafluoroethylene Nanoparticles under Pulsed Ultrasound Stimulation," Ultrason. Sonochem., 32, 1-7, 2016. 

C. Y. Lin, H. Y. Hsieh, C. M. Chen, S. R. Wu, C. H. Tsai, C. Y. Huang, M. Y. Hua, K. C. Wei, C. K. Yeh, H. L. Liu*, "Non-invasive, Neuron-Specific Gene Therapy by Focused Ultrasound-Induced Blood-Brain Barrier Opening in Parkinson’s Disease Mouse Model," J. Control. Release, 235, 72-81, 2016. 

H. Y. Huang, C. A. Lin*, W. H. Chang, C. K. Yeh, "Template-based Formation of Microbubble Ultrasound Contrast Agents," RSC Adv., 6(73), 69185-69190, 2016. 

C. H. Fan, Y. H. Cheng, C. Y. Ting, Y. J. Ho, P. H. Hsu, H. L Liu*, C. K. Yeh*, "Ultrasound/Magnetic Targeting with SPIO-DOX-Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors," Theranostics, 6(10), 1542-1556, 2016.

T. T. Kuo, M. R. Lee, Y. Y. Liao, J. P. Chen, Y. W. Hsu, C. K. Yeh*, "Assessment of Median Nerve Mobility by Ultrasound Dynamic Imaging for Diagnosing Carpal Tunnel Syndrome," PLoS ONE, 11(1), e0147051, 2016.

C. H. Fan, C. Y. Ting, C. Y. Lin, H. L. Chan, Y. C. Chang, Y. Y. Chen, H. L. Liu*, C. K. Yeh*, "Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson's Disease," Sci Rep, 6, 19579, 2016.

Y. J. Ho, Y. C. Chang, C. K. Yeh*, "Improving Nanoparticle Penetration in Tumors by Vascular Disruption with Acoustic Droplet Vaporization," Theranostics, 6(3), 392-403, 2016.

C. H. Fan, C. Y. Ting, Y. C. Chang, K. C. Wei, H. L. Liu*, C. K. Yeh*, "Drug-loaded Bubbles with Matched Focused Ultrasound Excitation for Concurrent Blood-Brain Barrier Opening and Brain-Tumor Drug Delivery," Acta Biomater., 15, 89-101, 2015. 

W. C. Huang, W. H. Chiang, Y. H. Cheng, W. C. Lin, C. F Yu, C. Y Yen, C. K. Yeh, C. S. Chern, C. S Chiang*, H. C. Chiu*, "Tumortropic Monocyte-Mediated Delivery of Echogenic Polymer Bubbles and Therapeutic Vesicles for Chemotherapy of Tumor Hypoxia," Biomaterials, 71, 71-83, 2015.

C. C. Hsieh, S. T. Kang, Y. H. Lin, Y. J. Ho, C. H. Wang, C. K. Yeh , C. W. Chang*, "Biomimetic Acoustically-Responsive Vesicles for Theranostic Applications," Theranostics, 5(11), 1264-1274, 2015.

C. Y. Lin, H. Y. Hsieh, W. G. Pitt, C. Y. Huang, I. C. Tseng, C. K. Yeh, K. C. Wei, H. L. Liu*, "Focused Ultrasound-Induced Blood-Brain Barrier Opening for Non-Viral, Non-invasive, and Targeted Gene Delivery," J. Control. Release, 212, 1-9, 2015.

S. T. Kang, J. L. Lin, C. H. Wang, Y. C. Chang, C. K. Yeh*, "Internal Polymer Scaffolding in Lipid-Coated Microbubbles for Control of Inertial Cavitation in Ultrasound Theranostics," J. Mat. Chem. B, 3(29), 5938-5941, 2015. 

W. T. Chen, S. T. Kang, J. L. Lin, C. H. Wang, R. C. Chen, C. K Yeh*, "Targeted Tumor Theranostics Using Folate-Conjugated and Camptothecin-Loaded Acoustic Nanodroplets in a Mouse Xenograft Model," Biomaterials, 53, 699-708, 2015.

Y. Y. Liao, W. N. Lee, M. J. Lee, W. S. Chen, H. J. Chiou, T. T. Kuo, C. K. Yeh*, "Carpal Tunnel Syndrome: US Strain Imaging for Diagnosis," Radiology, 275(1), 205-214, 2015.

Y. Y. Liao, C. H. Li, P. H. Tsui, C. C. Chang, W. H. Kuo, K. J. Chang, C. K. Yeh*, "Discrimination of Breast Microcalcifications Using a Strain-Compounding Technique with Ultrasound Speckle Factor Imaging," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 61(6), 955-965, 2014.

C. H. Fan, C. K. Yeh*, "Microbubble-Enhanced Focused Ultrasound-Induced Blood-Brain Barrier Opening for Local and Transient Drug Delivery in Central Nervous System Disease," J. Med. Ultrasound, 22(4), 183-193, 2014. (invited review article)

C. H. Fan, H. L. Liu, C. Y. Ting, Y. H. Lee, C. Y. Huang, Y. J. Ma, K. C. Wei, T. C. Yen*, C. K. Yeh*, "Submicron-Bubble-Enhanced Focused Ultrasound for Blood-Brain Barrier Disruption and Improved CNS Drug Delivery," PLoS ONE, 9(5), e96327, 2014.

C. H. Fan, W. H. Lin, C. Y. Ting, W. Y. Chai, T. C. Yen, H. L. Liu*, C. K. Yeh*, "Contrast-Enhanced Ultrasound Imaging for the Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening," Theranostics, 4(10), 1014-1025, 2014.

H. L. Liu, C. H. Fan, C. Y. Ting, C. K. Yeh*, "Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors: Current Progress and Overview," Theranostics, 4(4), 432-444, 2014. (Cover Image Illustration)

S. T. Kang, Y. C. Lin, C. K. Yeh*, "Mechanical Bioeffects of Acoustic Droplet Vaporization in Vessel-Mimicking Phantoms," Ultrason. Sonochem., 21(5), 1866-1874, 2014. 

S. T. Kang, Y. L. Huang, C. K. Yeh*, "Characterization of Acoustic Droplet Vaporization for Control of Bubble Generation under Flow Conditions," Ultrasound Med. Biol., 40(3), 551-561, 2014. 

J. J. Chen, C. H. Cheng, C. K. Yeh*, "Skin-Scanning Technique for Superficial Blood Flow Imaging Using a High-Frequency Ultrasound System," Ultrasonics, 54(1), 241-246, 2014. 

S. L. Peng, F. N. Wang*, C. H. Wang, H. H. Peng, C. K. Yeh, "Using Microbubbles as an MRI Contrast Agent for Measuring Cerebral Blood Volume," NMR Biomed., 26(11), 1540-1546, 2013.

S. T. Kang, C. K. Yeh*, "Trapping of a Mie Sphere by Acoustic Pulses: Effects of Pulse Length," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 60(7), 1487-1497, 2013.

C. H. Fan, C. Y. Ting, H. J. Lin, C. H. Wang, H. L. Liu*, T. C. Yen, C. K. Yeh*, "SPIO-Conjugated, Doxorubicin-Loaded Microbubbles for Concurrent MRI and Focused-Ultrasound Enhanced Brain-Tumor Drug Delivery," Biomaterials, 34(14), 3706-3715, 2013.

C. H. Wang, S. T. Kang, C. K. Yeh*, "Superparamagnetic Iron Oxide and Drug Complex-Embedded Acoustic Droplets for Ultrasound Targeted Theranosis," Biomaterials, 34(7), 1852-1861, 2013.

C. H. Fan, C. Y. Ting, H. L. Liu*, C. Y. Huang, H. Y. Hsieh, T. C. Yen, K. C. Wei, C. K. Yeh*, "Antiangiogenic-Targeting Drug-Loaded Microbubbles Combined With Focused Ultrasound for Glioma Treatment," Biomaterials, 34(8), 2142-2155, 2013. 

F. Yan, L. Li, Z. Deng, W. Yang, J. Chen, Q. Jin, C. K. Yeh, J. Wu, R. Shandas, X. Liu, H. Zheng*, "Paclitaxel-liposome-microbubble Complexes as Ultrasound-Triggered Therapeutic Drug Delivery Carriers," J. Control. Release, 166(3), 246-255, 2013.

 J. J. Chen, S. Y. Fu, C. S. Chiang, J. H. Hong, C. K. Yeh*, "A Preclinical Study to Explore Vasculature Differences Between Primary and Recurrent Tumors Using Ultrasound Doppler Imaging," Ultrasound Med. Biol., 39(5), 860-869, 2013.

C. H. Wang, C. K. Yeh*, "Controlling the Size Distribution of Lipid-Coated Bubbles via Fluidity Regulation," Ultrasound Med. Biol., 39(5), 882-892, 2013. 

C. H. Wang, S. T. Kang, Y. H. Lee, Y. L. Luo, Y. F. Huang, C. K. Yeh*, "Aptamer-Conjugated and Drug-Loaded Acoustic Droplets for Ultrasound Theranosis," Biomaterials, 33(6), 1939-1947, 2012.

J. J. Chen, S. Y. Fu, C. S. Chiang, J. H. Hong, C. K. Yeh*, "Characterization of Tumor Vasculature Distributions in Central and Peripheral Regions Based on Doppler Ultrasound," Med. Phys., 39(12), 7490-7498, 2012.

Y. Y. Liao, C. C. Wu, T. T. Kuo, J. P. Chen, Y. W. Hsu, C. K. Yeh*, "Carpal Tunnel Syndrome Diagnosis by a Self-Normalization Process and Ultrasound Compound Imaging," Med. Phys., 39(12), 7402-7411, 2012.

C. H. Fan, H. L. Liu, C. Y. Huang, Y. J. Ma, T. C. Yen*, C. K. Yeh*, "Detection of Intracerebral Hemorrhage and Transient Blood-Supply Shortage in Focused-Ultrasound-Induced Blood-Brain Barrier Disruption by Ultrasound Imaging," Ultrasound Med. Biol., 38(8), 1372-1382, 2012.

P. Chonpathompikunlert, C. H. Fan, Y. Ozaki, T. Yoshitomi, C. K. Yeh, Y. Nagasaki*, "Redox Nanoparticle Treatment Protects Against Neurological Deficit in Focused Ultrasound-Induced Intracerebral Hemorrhage," Nanomedicine, 7(7), 1029-1043, 2012.

C. A. J. Lin*, W. K. Chuang, Z. Y. Huang, S. T. Kang, C. Y. Chang, C. T. Chen, J. L. Li, J. K. J. Li, H. H. Wang, F. C. Kung, J. L. Shen, W. H. Chan, C. K. Yeh, H. I. Yeh, W. F. T. Lai*, W. H. Chang*, "Rapid Transformation of Protein-caged Nanomaterials into Microbubbles as Bimodal Imaging Agents," ACS Nano, 6(6), 5111-5121, 2012.

P. H. Tsui*, C. K. Yeh, C. C. Huang, "Noise-Assisted Correlation Algorithm for Suppressing Noise-Induced Artifacts in Ultrasonic Nakagami Images," IEEE T. Inf. Technol. Biomed., 16(3), 314-322, 2012.

Y. Y. Liao, C. H. Li, P. H. Tsui, C. C. Chang, W. H. Kuo, K. J. Chang, C. K. Yeh*, "Strain-Compounding Technique with Ultrasound Nakagami Imaging for Distinguishing Between Benign and Malignant Breast Tumors," Med. Phys., 39(5), 2325-2333, 2012.

C. Y. Ting, C. H. Fan, H. L. Liu*, C. Y. Huang, H. Y. Hsieh, T. C. Yen, K. C. Wei, C. K. Yeh*, "Concurrent Blood-Brain Barrier Opening and Local Drug Delivery Using Drug-Carrying Microbubbles and Focused Ultrasound for Brain Glioma Treatment," Biomaterials, 33(2), 704-712, 2012.

S. T. Kang, C. K. Yeh*, "Ultrasound Microbubble Contrast Agents for Diagnostic and Therapeutic Applications: Current status and future design," Chang Gung Medical Journal, 35(2), 125-139, 2012. (invited review article)

C. C. Shen, S. Y. Su, C. H. Cheng, C. K. Yeh*, "Phantom Investigation of Phase-Inversion-Based Dual-Frequency Excitation Imaging for Improved Contrast Display," Ultrasonics, 52(1), 25-32, 2012. 

W. S. Chen, C. C. Shen, J. C. Wang, C. T. Ko, H. L. Liu, M. C. Ho, C. N. Chen, C. K. Yeh*, "Single-Element Ultrasound Transducer for Combined Vessel Localization and Ablation," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 58(4), 766-775, 2011.

J. J. Chen, J. J. J. Chen, C. S. Chiang, J. H. Hong, C. K. Yeh*, "Assessment of Tumor Vasculature for Diagnostic and Therapeutic Applications in a Mouse Model in vivo Using 25-MHz Power Doppler Imaging," Ultrasonics, 51(8), 925-931, 2011.

S. T. Kang, C. K. Yeh*, "Intracellular Acoustic Droplet Vaporization in a Single Peritoneal Macrophage for Drug Delivery Applications," Langmuir, 27(21), 13183-13188, 2011.

C. C. Shen, C. H. Cheng, C. K. Yeh*, "Phase-Dependent Dual-Frequency Contrast Imaging at Sub-Harmonic Frequency," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 58(2), 379-388, 2011. 

Y. Y. Liao, J. C. Wu, C. H. Li, C. K. Yeh*, "Texture Feature Analysis for Breast Ultrasound Image Enhancement," Ultrason. Imaging, 33(4), 264-278, 2011.

Y. Y. Liao, P. H. Tsui, C. H. Li, K. J. Chang, W. H. Kuo, C. C. Chang, C. K. Yeh*, "Classification of Scattering Media within Benign and Malignant Breast Tumors Based on Ultrasound Texture-Feature-Based and Nakagami-Parameter Images," Med. Phys., 38(4), 2198-2207, 2011. 

C. H. Wang, Y. F. Huang, C. K. Yeh*, "Aptamer-Conjugated Nanobubbles for Targeted Ultrasound Molecular Imaging," Langmuir, 27(11), 6971-6976, 2011.

S. H. Hung, C. K. Yeh, T. H. Tsai, T. Chen, R. C. Chen*, "A Simple Method for Quantifying Ultrasound-Triggered Microbubble Destruction," Ultrasound Med. Biol., 37(6), 949-957, 2011.

C. H. Cheng, C. C. Shen, C. K. Yeh*, "Dual-Frequency Chirp Imaging for Contrast Detection," Phys. Med. Biol., 56(9), 2767-2778, 2011.

S. T. Kang, C. K. Yeh*, "A Maleimide-Based In-Vitro Model for Ultrasound Targeted Imaging," Ultrason. Sonochem., 18(1), 327-333, 2011.

M. L. Li, Y. C. Kuo, C. K. Yeh*, "Amplitude-Modulation Chirp Imaging for Contrast Detection," Ultrasound Med. Biol., 36(9), 1535-1545, 2010.

C. C. Shen., S. Y. Su., C. H. Cheng, C. K. Yeh*, "Dual-High-Frequency Ultrasound Excitation on Microbubble Destruction Volume," Ultrasonics, 50(7), 698-703, 2010.

S. T. Kang, C. K. Yeh*, "Potential-Well Model in Acoustic Tweezers," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 57(6), 1451-1459, 2010.

P. H. Tsui, Y. Y. Liao, C. C. Chang, W. H. Kuo, K. J. Chang, C. K. Yeh*, "Classification of Benign and Malignant Breast Tumors by 2-d Analysis Based on Contour Description and Scatterer Characterization," IEEE Trans. Med. Imaging, 29(2), 513-522, 2010.

P. H. Tsui, C. K. Yeh, Y. Y. Liao, C. C. Chang*, W. H. Kuo, K. J. Chang, "Ultrasonic Nakagami Imaging: A Strategy to Visualize the Scatterer Properties of Benign and Malignant Breast Tumors," Ultrasound Med. Biol., 36(2), 209-217, 2010. 

Y. Y. Liao, P. H. Tsui, C. K. Yeh*, "Classification of Benign and Malignant Breast Tumors by Ultrasound B-scan and Nakagami-based Images," J. Med. Biol. Eng., 30(5), 307-312, 2010. (JMBE Annual Best Paper Award)

P. H. Tsui, C. K. Yeh*, C. C. Chang*, "Microvascular Flow Estimation by Contrast-assisted Ultrasound B-scan and Statistical Parametric Images," IEEE T. Inf. Technol. Biomed., 13(3), 360-369, 2009. (Cover Image Illustration)

C. K. Yeh, S. Y. Su, C. C. Shen*, "Microbubble destruction by dual-high-frequency ultrasound excitation," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 56(5), 1113-1118, 2009.

C. K. Yeh*, Y. S. Chen, W. C. Fan, Y. Y. Liao, "A Disk Expansion Segmentation Method for Ultrasonic Breast Lesions," Pattern Recognit., 42(5), 596-606, 2009. 

C. K. Yeh*, J. J. Chen, M. L. Li, J. J. Lu, J. J. Chen, "In Vivo Imaging of Blood Flow in the Mouse Achilles Tendon Using High-Frequency Ultrasound," Ultrasonics, 49(2), 226-230, 2009.

P. H. Tsui, C. K. Yeh*, C. C. Chang, "Microvascular Flow Estimation by Microbubble-Assisted Nakagami Imaging," Ultrasound Med. Biol., 35(4), 653-671, 2009.

C. C. Shen*, C. K. Yeh, W. S. Chen, H. W. Wang, "The effect of third harmonic transmit phasing on contrast agent responses for CTR improvement," Phys. Med. Biol., 53(21), 6179-6194, 2008.

P. H. Tsui, C. K. Yeh*, C. C. Chang*, Y. Y. Liao, "Classification of Breast Masses by Ultrasonic Nakagami Imaging: A Feasibility Study," Phys. Med. Biol., 53(21), 6027-6044, 2008.

C. K. Yeh*, S. Y. Su, C. C. Shen, M. L. Li, "Dual High-Frequency Difference Excitation for Contrast Detection," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 55(10), 2164-2176, 2008. 

C. K. Yeh*, S. Y. Su, "Effects of Acoustic Insonation Parameters on Microbubbles Destruction," Ultrasound Med. Biol., 34(8), 1281-1291, 2008.

C. C. Shen*, Y. C. Wang, C. K. Yeh, "Imaging Parameters on Third Harmonic Transmit Phasing for Tissue Harmonic Generation," Ultrasound Med. Biol., 34(6), 1001-1013, 2008.

C. K. Yeh*, C. H. Chunh, J. J. Chen, J. J. Chen, "High-Frequency Ultrasonic Imaging System: A Preliminary Small Animals Study," Int. J. Elec. Eng., 15(3), 195-202, 2008.

P. H. Tsui, C. K. Yeh*, C. C. Chang*, "Feasibility Exploration of Blood Flow Estimation by Contrast-Assisted Nakagami Imaging," Ultrason. Imaging, 30(3), 133-150, 2008.

P. H. Tsui, C. K. Yeh*, C. C. Chang*, W. S. Chen, "Performance Evaluation of Ultrasonic Nakagami Image in Tissue Characterization," Ultrason. Imaging, 30(2), 78-94, 2008.

P. H. Tsui, C. K. Yeh*, C. C. Chang*, "Noise Effect on the Performance of Nakagami Image in Ultrasound Tissue Characterization," J. Med. Biol. Eng., 28(4), 197-202, 2008.

L. F. Liu, C. K. Yeh, C. H. Chen, T. W. Wong, J. J. Chen*, "Measurement of Cerebral Blood Flow and Oxygen Saturation Using Laser Doppler Flowmetry anal Near Infrared Spectroscopy in Ischemic Stroke Rats," J. Med. Biol. Eng., 28(2), 101-105, 2008.

C. K. Yeh*, S. Y. Lu, Y. S. Chen, "Microcirculation Volumetric Flow Assessment Using High-Resolution, Contrast-Assisted Images," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 55(1), 74-83, 2008.

C. K. Yeh*, S. Y. Su, W. S. Chen, "Destruction Threshold Parameters Estimation for Ultrasonic Contrast Agents," J. Med. Biol. Eng., 25(4), 159-163, 2005.

C. K. Yeh*, W. S. Chen, P. M. Ma, "Ultrasonic Image Enhanced by Shockwave-induced Cavitation," J. Med. Biol. Eng., 25(4), 143-151, 2005.

C. K. Yeh*, W. S. Chen, P. M. Ma, H. L. Liu, M. S. Chen, C. W. Chang, "A novel method for estimating the focal size of two confocal high-intensity focused ultrasound transducers," J. Acoust. Soc. Am., 117(6), 3740-3749, 2005.

C. K. Yeh, K. W. Ferrara, D. E. Kruse, "High-resolution functional vascular assessment with ultrasound," IEEE Trans. Med. Imaging, 23(10), 1263-1275, 2004.

C. K. Yeh, M. J. Yang, P. C. Li, "Contrast-specific ultrasonic flow measurements based on both input and output time intensities," Ultrasound Med. Biol., 29(5), 671-678, 2003.

C. K. Yeh, P. C. Li, "Doppler angle estimation of pulsatile flows using AR modeling," Ultrason. Imaging, 24(2), 65-80, 2002.

C. K. Yeh, P. C. Li, "Doppler angle estimation using AR modeling," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 49(6), 683-692, 2002. 

P. C. Li, C. K. Yeh, S. W. Wang, "Time-intensity-based volumetric flow measurements: an in vitro study," Ultrasound Med. Biol., 28(3), 349-358, 2002. 

P. C. Li, C. J. Cheng, C. K. Yeh, "On velocity estimation using speckle decorrelation," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 48(4), 1084-1091, 2001.

C. K. Yeh, S. W. Wang, P. C. Li, "Feasibility study of time-intensity-based blood flow measurements using deconvolution," Ultrason. Imaging, 23(2), 90-105, 2001.

J. J. Chen, C. K. Yeh, J. J. Tsai, "Initial estimation methods for dipole modeling in localization of epileptogenic focus," Med. Eng. Phys., 20, 11-20, 1998.

J. J. Chen, J. J. Tsai, C. H. Sheu, H. Y. Lin, C. K. Yeh, "Application of dipole modeling in localization of mesio-temporal epileptogenic focus," Proceedings of the National Science Council, ROC. Part B: Life Sciences, 21(2), 61-70, 1997.