Method for Normalizing Blood Vessels of Lesions by Oxygen-Loaded Microbubbles and Ultrasonic Irradiation

用以誘導病變組織血管正常化的套組及其用途

中華民國：I686210

CN 4998837
US 10835603B2

Shu-Wei Chu, Yi-Ju Ho, Chih-Kuang Yeh

朱書葦、何奕儒、葉秩光

A method for normalizing blood vessels of lesions is disclosed, which includes administering an effective amount of oxygen-loaded microbubbles to a subject in need by intravenous injection, and projecting ultrasound from a ultrasonic emission device into the lesions for rupturing the oxygen-loaded microbubbles and releasing the oxygen to the lesions. Each of the oxygen-loaded microbubbles comprises oxygen and a water insoluble gas, and the particle size of microbubbles is 0.5~20 μm.

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本發明有關於一種帶氧微氣泡用於製備誘導病變組織血管正常化套組之用途，其中，該帶氧微氣泡包含一氧氣以及一難溶於水的氣體，且該帶氧微氣泡的粒徑為0.5~20μm； 其中， 該套組包括一帶氧微氣泡混合液、以及一超音波發射裝置；一有效劑量之該氧微氣泡係以靜脈注射進入生物體內，再使用超音波發射裝置照射該病變組織，使得該帶氧微氣泡於該病變組織處破裂而釋放氧氣。